Taxomyces andreanae is an endophytic fungus of the class hyphomycetes which colonize the intra or intercellular regions of the plant to establish a symbiotic interaction. These fungi are capable of producing various secondary bioactive metabolites which possess anti-microbial and anticancerous properties.one such compound is Taxol. In addition, in a symbiotic association, Taxomyces andreanae increase the resistance of plant towards abiotic /biotic stresses.

This manuscript addresses the top 25 companies committed to biotechnology therapeutics that change over time covering their history over past 25 years through 2023. Furthermore, key issues include their productivity in product numbers, sales of products and companies, the types of molecules, the impact of in-licensing and out-licensing versus internal product development, engagement by new versus established companies, impact of major mergers and acquisitions, FDA approval history especially for novel products [biotech versus drugs], research funding and partnership funding by pharma for biotech, and the top biotech products by these companies as well. Numerous tables provide the extensive data supporting these company and biotechnology issues.  These top 25 companies committed to biotechnology therapeutics have marketed over 50% of all biotech products, out of the 275 companies with biotech products, especially the leaders throughout the 25 years – Roche, Amgen, Novo Nordisk, Biogen, Eli Lilly, Johnson & Johnsson, Novartis, and Sanofi. The whole biopharma industry across the world is now heavily committed to biotechnology products. These companies have acquired the majority of their biotech products [versus internal development], especially through mergers and acquisitions.